Monday, December 1, 2014

Vitamin A and Stargardt's - Part 1

The only advice I was given when diagnosed with SD was that vitamin A was causing my vision loss and to not take supplements with Vitamin A. This totally contradicts the widely known fact that Vitamin A is essential for eyes. It's not that this fact is incorrect, it's that it doesn't wholly apply to SD. 

Since I love my science and research, I took it upon myself to spend my spare time reading every published article on SD and vitamin A to find out more about the mechanisms at play in the eye causing problems and what evidence exists to support these theories. The earliest article I found was published in 2008 and all used mouse models for investigations.

A paper published in Cell Death and Disease this year gives a good overview of the mechanism leading to vision loss and how Vitamin A is implicated. Essentially, SD is caused by an accumulation in the RPE of Vitamin A dimers (dimers are two molecules joined chemically), which are known as A2E (shortened version of the chemical name). Using an in vivo model, they found that increased A2E led to greater cell death. A word that always comes up when talking about SD is lipofuscin which is the yellow-brownish pigment deposits seen on a retinal scan used to diagnose the condition. Tying it all together, A2E derived from vitamin A is a retinal lipofuscin which is causing the damage and subsequent vision loss. These findings support earlier studies in mice such as articles n the Journal of Biological Chemistry and Investigative Ophthalmology and Visual Science which both looked at the effects of vitamin A, SD and mice demonstrating that higher doses of vitamin A led to increased lipofuscin development. 

Another paper in the Journal of Biological Chemistry also used a mouse model to investigate the effects of A2E and  also oxidative stress. It was found that A2E increased inflammation in the RPE, which is an important finding for prospective treatment solutions.
 
There are no studies performed in humans on the effects of vitamin A probably because it is not exactly ethical to get a group of SD patients and give them high doses of vitamin A and see whether they deteriorate! Despite this, the research is available to support that vitamin A is indeed causing damage in the eye and leading to vision loss. The continuing research has led to greater understanding on the different components at play and, no doubt, will help in the future to develop therapies. 

So now we know vitamin A is not our best friend, where do we go from here? Part 2 will discuss diet and vitamin A and how we can ensure not to overload vitamin A and contribute to the SD process.


117 comments:

  1. I read your blog! It is nice and useful. Vitamin 'A' is a very important vitamin for eyes. It makes a huge effect on eyes and it's light. It helps to control blindness. Really it's a great work. Keep it up.
    Buy Eye Care Medicine Online

    ReplyDelete
    Replies
    1. https://www.lillyputinterio.in/products/display-cabinet-cube-unit-bookcase-71

      Delete
  2. I really loved the way you have written this post. Really this is an outstanding post. I was quite amazed after seeing this post. I'll share this with my friends also. High Blood Pressure Diet || Non Communicable Disease || Foods in Different Languages

    ReplyDelete
    Replies
    1. for website design contact http://googleads.co.in/

      Delete
  3. A very awesome blog indeed. I really like it. It has all the things that a best post has. Legit Information. Best Use of Words etc. Keep working good like this. Cholesterol Lowering Foods || Diet for Glowing Skin || Diabetic Diet

    ReplyDelete
    Replies
    1. packers and movers in delhi visit http://5toppackersandmovers.com/

      Delete

  4. This is my first time i visit here. I found so many interesting stuff in your blog especially its discussion. From the tons of comments on your blog, I guess I am not the only one having all the enjoyment here! keep up the good work. Weight Management || Causes of High Blood Pressure || Healthy Diet

    ReplyDelete
  5. This blog is beautifully written. I really like the way you've presented the blog. I would like that you continue this amazing work. Cheers! Balanced Diet || Diet Plan || Balanced Diet Plan

    ReplyDelete
    Replies
    1. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/

      Delete
  6. Replies
    1. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/advanced-course/

      Delete
  7. Such a great blog! Thank you for sharing this information. Did you write a Part II? I can’t find it, only the earlier posts. Thanks

    ReplyDelete
    Replies
    1. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/mobile-marketing/

      Delete
  8. There is lot of articles on the web about this. But I like yours more, although i found one that’s more descriptive.
    collagen supplements

    ReplyDelete
    Replies
    1. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/google-analytics/

      Delete
  9. Packers and Movers in Delhi @ http://3th.co.in/packers-and-movers-delhi/
    Packers and Movers Faridabad@ http://3th.co.in/packers-and-movers-faridabad/
    Packers and Movers Noida@ http://3th.co.in/packers-and-movers-noida/
    Packers and Movers Ghaziabad @ http://3th.co.in/packers-and-movers-ghaziabad/

    ReplyDelete
    Replies
    1. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/email-marketing/

      Delete
  10. Hi – It’s good to read such interesting content. I agree with much of what is written here and I’ll be coming back.
    Thanks again for posting such great reading material!! To get more relevant information visit here
    BrainPlus IQ
    BrainPlus IQ reviews

    ReplyDelete
  11. Hi – It’s good to read such interesting content. I agree with much of what is written here and I’ll be coming back.
    Thanks again for posting such great reading material!! To get more relevant information visit here
    Packers and Movers Noida
    http://blog.packers-and-movers-delhi.in/
    http://packers-and-movers-delhi.in/packers-and-movers-dwarka-delhi

    ReplyDelete
    Replies
    1. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/content-marketing/

      Delete
  12. Thanks for sharing such a informative article. I hope that this post is really useful for the people who looks for this. please Also check the below links: Packers And Movers Bangalore Rough Charges Of Moving Organizations In Bangalore
    http://packers-and-movers-bangalore.in/packers-and-movers-electronics-city-bengaluru
    http://packers-and-movers-bangalore.in/packers-and-movers-domlur-bengaluru

    ReplyDelete
  13. Your blog provided us with valuable information to work with.Each & every tips of your post are awesome. Thanks a lot for sharing. Keep blogging..https://medium.com/@irshadseo/rise-your-brand-awareness-impeccably-by-purchasing-real-instagram-followers-2a53e0b8d8a#.87peops14

    ReplyDelete
  14. We know you were considering about de-cluttering at least few time per year. While it’s the best factor to do it at any time when you look and experience confused with old factors you keep under no circumstances. Still – there is a high probability you only think to do it, but never actually do it.

    Packers and Movers in Mumbai
    Packers and Movers in Pune
    Packers and Movers in Gurgaon
    Packers and Movers in Bangalore

    ReplyDelete
  15. This is the first time i am reading your post and admire that you posted article which gives users lot of information regarding particular topic thanks for this share.phytoberry

    ReplyDelete
  16. A superb transferring company provides an update choice, guaranteeing each load connected with furniture for its true substitution or perhaps fix importance, having or perhaps with no tax deductible. Your totally included mover wouldn't normally pay out anything for the fix. This can be termed non-deductible value.
    Packers and Movers in Chandigarh
    Packers and Movers in Chennai
    Packers and Movers in Hyderabad
    Packers and Movers in Mumbai
    Packers and Movers in Gurgaon

    ReplyDelete

  17. Nice post share for this topics and join all people to each other that share best ideas and services.
    superbrandsdigital
    fl-tek

    ReplyDelete
  18. Thanks for share this Post to communicate all member to each other and get best ideas and tips on any topics for better knowledge.
    UK-Europe-Article
    idleexperts

    ReplyDelete
  19. If you are been in a relationship for some day Online Cake Delivery Delhi time a dozen or even two dozen of Online Cake these beauties will surely melt your lover’s heart a new Cake Delivery Delhi.
    Online Cake Delivery in Delhi
    http://onlinecakeorder.in/

    ReplyDelete
  20. I have not heard about before. Keep sharing more blog posts on this Community and get extra benefits with this ideas and knowledge. Thanks for this one.
    mediafire
    edocr
    4shared
    4sharedompe

    ReplyDelete
  21. Do you need a quick long or short term loan with a relatively low interest rate as low as 3%? We offer Xmas loan, business loan, personal loan, home loan, auto loan,student loan, debt consolidation loan e.t.c. no matter your score, If yes contact us via Email: finance2014911@gmail.com Fill The Loan Application Form Below Name............ Amount Needed........ Duration.......... Country............ Monthly income....... Age............. Phone Number........ Sex ................. Email................Business Plan/Use Of Your Loan:....... Apply now on this email :finance2014911@gmail.com Warm Regards Dr Purva Sharegistry

    ReplyDelete
  22. I really like the way how you described all your research since i was diagnosed last week with stargardt and had started with some of the symptoms of the disease i had been researching what is the main cause of the central loss vision and how to delay the process or at least fight it back to retain my vision as long as i can.

    i will be reading your other posts on my spare time and looking for the diet post.

    ReplyDelete
  23. Packers and Movers in Sonipat movers and packers in Sonipat
    http://www.packersmoversindia.org/packers-and-movers-sonipat.html

    Packers and Movers Zirakpur Movers and packers in Zirakpur
    http://www.packersmoversindia.org/packers-and-movers-zirakpur.html

    Packers and Movers in Pathankot Movers and packers in Pathankot
    http://www.packersmoversindia.org/packers-and-movers-pathankot.html

    ReplyDelete
  24. Panther Packer is leading Packers Company in Karachi as we are offering best packer and movers services in all over Pakistan as we are best Movers and Packers in Karachi.
    Packers and Mover Company Karachi

    ReplyDelete
  25. Awesome Ideas to Impress your Brother with a Rakhi Gift On Raksha Bandhan.
    http://www.rakhiinindia.in/
    http://www.rakhiinindia.in/rakhi-delivery-in-ahmedabad.html
    http://www.rakhiinindia.in/rakhi-delivery-in-bangalore.html
    http://www.rakhiinindia.in/rakhi-delivery-in-bhopal.html
    http://www.rakhiinindia.in/rakhi-delivery-in-chandigarh.html
    http://www.rakhiinindia.in/rakhi-delivery-in-chennai.html
    http://www.rakhiinindia.in/rakhi-delivery-in-coimbatore.html

    ReplyDelete
  26. This Year’s Make Your Raksha Bandhan Remarkable for Your Brother with Miraculous Rakhi Gifts in all Over India.
    http://www.rakhiinindia.in/rakhi-delivery-in-kota.html
    http://www.rakhiinindia.in/rakhi-delivery-in-mumbai.html
    http://www.rakhiinindia.in/rakhi-delivery-in-noida.html
    http://www.rakhiinindia.in/rakhi-delivery-in-patna.html
    http://www.rakhiinindia.in/rakhi-delivery-in-pune.html
    http://www.rakhiinindia.in/rakhi-delivery-in-roorkee.html

    ReplyDelete
  27. "Pretty article! I found some useful information in your blog, it was awesome to read, thanks for sharing this great content to my vision, keep sharing.."!!

    Best doctor for treatment of Heart Failure treatment in Indore

    ReplyDelete
  28. Thanks for share this Post to communicate all member to each other and get best ideas and tips on any topics for better knowledge.
    Please click to play,if you wanna join casino online. Thank you
    จีคลับ
    gclub online
    gclub casino

    ReplyDelete
  29. Vitamins are very important for the proper functioning and health of the body. Vitamin chart should be at every home and people should eat as per the chart. Vitamins and proteins keep you healthy and give you long life. Find more discussion at our Question and Answer Website.

    ReplyDelete
  30. A fantastic blog with a lot of useful information. I would like to get updates from you. Keep blogging. All the best.

    Vansh Packers and Movers Agra is well known for their moving services and quality and

    Economical packing. Vansh Packers and Movers are considered to be one of the best packers and movers company in Agra.

    More Cities Packing Moving Service Provide Best Services as following below.

    Packers and Movers Mathura
    Packers and Movers Firozabad
    Packers and Movers Aligarh
    Packers and Movers Etawah

    Thanks and Best Regards
    Hotam Singh (Owner)
    +91-9675774777 | 8006720005 | 9627006767
    http://www.packersandmoversagra.com

    ReplyDelete
  31. http://5toppackersandmovers.com/packers-movers-gurgaon/5-top-packers-movers-sohna-road/

    ReplyDelete
  32. http://digitalmarketinginstituteinindore.com/

    ReplyDelete
  33. https://www.lillyputinterio.in/products/kids-panda-single-bed

    ReplyDelete
  34. https://www.lillyputinterio.in/products/display-cabinet-cube-unit-bookcase-71

    ReplyDelete
  35. http://digitalmarketinginstituteinindore.com/about/

    ReplyDelete
  36. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/social-media-marketing/

    ReplyDelete
  37. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/online-display-advertising/

    ReplyDelete
  38. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/lead-generation-for-business/

    ReplyDelete
  39. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/social-media-marketing/

    ReplyDelete
  40. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/content-marketing/

    ReplyDelete
  41. http://digitalmarketinginstituteinindore.com/digital-marketing-institute/content-marketing/

    ReplyDelete
  42. Pet Sheet Lila Pack is top pet sheet and pet sheet related Manufacturers from Mumbai – APet Sheet, RPet Sheet, Hips Sheet, Pet Sheet Manufacturers, Suppliers and Exporters in Mumbai,Gujarat,Delhi,Bangalore,Pune,Chennai.

    ReplyDelete
  43. Foogle Packers Movers India is the best mover and packers. At this time for Away online business are perfect processes by the or hassle for header top packers and movers in India. At a random the wonderful according’s the thought nicely or very Google Couse a better of the day a satisfied customers are function needs forever contended too boots our in doing great packing and moving all most usefully services in India.

    http://www.fooglepackers.com/

    ReplyDelete
  44. Thank you for posting such a great article! I found your website perfect for my needs. It contains wonderful and helpful posts. Keep up the good work. Movers in Florida

    Movers, Florida

    ReplyDelete
  45. packers and movers in Laxmi Nagar are best services in delhi

    digital marketing institute in Indore
    are providing courses and trainning with 100% placement

    ReplyDelete
  46. Packers and movers in beml layout
    These service providers handle all kinds of moving in a simple manner. So people can hire without any tension the relocation services anytime and anywhere. Packers and Movers bangalore based service providers are always ready to handle through their good coordination.

    ReplyDelete
  47. This comment has been removed by the author.

    ReplyDelete
  48. Nice Information! I personally really appreciate your article and images on your blog post.

    Vansh Packers and Movers Agra also offer packers and movers services in Agra and across all towns and cities in India. More visit :- http://www.packersandmoversagra.com/

    More Cities Packing Moving Service Provide Best Services as following below.

    Packers and Movers Pune
    Packers and Movers Lucknow
    Packers and Movers Mainpuri
    Packers and Movers Jhansi
    Packers and Movers Hyderabad
    Packers and Movers Kanpur

    Thanks
    Hotam Singh
    +91-9675774777, 8006720005, 9627006767
    www.packersandmoversagra.com
    vanshpackers.agra@gmail.com

    ReplyDelete
  49. This blog is really helpful regarding all educational knowledge I earned. It covered a great area of subject which can assist a lot of needy people. Everything mentioned here is clear and very useful. เคืองตา

    ReplyDelete
  50. Rousing. I'm set for break out the old earth, myself. Much obliged for sharing.

    shoes online reviews

    ReplyDelete
  51. krishnafurniture offers

    https://krishnafurniture.com/office-desks
    https://krishnafurniture.com/study-chairs/study-chair
    https://krishnafurniture.com/bedroom-storage/wardrobe
    https://krishnafurniture.com/dining-table/crocekry-cabinet

    ReplyDelete
  52. Samira Gupta provides

    http://samiragupta.com
    http://samiragupta.com/life-coaching

    ReplyDelete
  53. This blog is beautifully written. I really like the way you've presented the blog. I would like that you continue this amazing work. A Vitamini Cheers!

    ReplyDelete
  54. Very Nice Article to read. Blog articles helped me alot in many ways to find the good solution. Am very happy to comments here. Thanks for sharing this kind of wonderful article in this blog. Lovely ! Kindly visit us @ CCTV Camera Supplier | MATRIX dealers

    ReplyDelete
  55. Amazing article. Your blog helped me to improve myself in many ways thanks for sharing this kind of wonderful informative blogs in live. I have bookmarked more article from this website. Such a nice blog you are providing ! Kindly Visit Us @
    Best Travels in Madurai | Tours and Travels in Madurai | Madurai Travels

    ReplyDelete
  56. We are Offering Movers and packers Services With Flexible Quotes and affordable Rates
    Movers and packers in Karachi

    ReplyDelete
  57. Thanks for sharing such kind of post! I have gone through with your article, the data are given in a very good manner.
    Kids Dentist in Greater Noida
    periodontics dentist in Greater Noida

    ReplyDelete
  58. We are Offering Movers and Packers Services with Flexible quotes and Reasonable Rates and Reliable Services.
    Movers and Packers in Karachi

    ReplyDelete
  59. Excellent post!
    I really appreciated that.thanks for sharing with us.
    Packers and Movers in Islamabad

    ReplyDelete
  60. My husband was diagnosed with MND ALS (amyotrophic lateral sclerosis) when he was 69 years old 6 years ago. The Rilutek (riluzole) did very little to help him. The medical team did even less. His decline was rapid and devastating. The psychological support from the medical center was non-existent and if it were not for totalcureherbsfoundation .c om and the sensitive cure of their herbal formula he would have been not been alive today,there was significant improvement in the first 4 weeks of usage that gave us hope that he will be alive,His doctor put him on riluzole, letting us know there was no cure until we gave try on total cure herbal supplement that cure him totally from this disease after 15 weeks of his usage. There is nothing positive about cure ALS condition except for their herbal treatment .

    ReplyDelete
  61. Thank you for sharing this article with us! I believe there will be more people like me, they can find many sangam packers
    I am happy to find this post very useful for me, as it contains lot of information. I always prefer to read the quality content and this thing I found in you post. 
    Click Here to Get More Sites readmore
    packers and movers allhabad
    packers and movers varanasi
    Packers and Movers Allahabad-Sangam @09005203241 movers and packers allahabad

    ReplyDelete
  62. It should be noted that whilst ordering papers for sale at paper writing service, you can get unkind attitude. In case you feel that the bureau is trying to cheat you, don't buy term paper from it. el mejor magnesio para tomar

    ReplyDelete
  63. Hello! I'm very excited to inform everyone that I'm completely cured from my HSV 1&2 recently. I have used Oregano oil, Coconut oil, Acyclovir, Valacyclovir, Famciclovir, and some other products and it's really help during my outbreaks but I totally got cured from my HSV with a strong and active herbal medicine ordered from a powerful herbalist and it completely fought the virus from my nervous system and I was tested negative after 12 days of using the herbal medicine. I'm here to let y'all know that herpes virus has a complete cure, I got rid of mine with the help of DR ANUGE and his herbal exploit. Contact him via email: dranuge@gmail.com or +2348164866838

    ReplyDelete
  64. Are you searching for Bulk chemical suppliers in USA ? Eastarchem is the Best Bulk chemical suppliers in USA Our associations with leading industry suppliers across the globe enable us to provide clienteles with the bulk volumes of critical commodity chemical products required for their operations.

    ReplyDelete
  65. Starway International Packers and Movers
    We take pleasure to introduce ourselves as one of the leading team of packers and movers in India.

    For Domestic & International packers and movers across the Globe. Being a professional & experienced packers, Star Way International Packers And Movers are here to shift your valuable & precious house hold goods to your destination - safely and in time.

    By different carrier vehicles, We move your household items to reach the destination. We have huge warehouses to store your goods if necessary.

    On your confirmation, our supervisor along with packers will Come and inspect the Goods and give the estimate for packing moving transportation Loading and unloading unpacking rearranging the House hold Goods / Corporate relocation / Commercial goods as per your requirement we will quote the quotation. We have good experience in this field we do proper and neat work orderly, each & every item in a safe manner. Each item will be marked and a inspection list will be prepared. Utmost care will be taken for all the Goods.

    Un-packing and rearranging the household goods are also done and that is supervised by our people up to your satisfaction. We have well experience trained packers to take care of your valuable & precious house hold goods or office Goods or Commercial Goods to your destination - safely and in time. We will pack & move House hold Goods / Corporate relocation / Commercial goods

    ReplyDelete
  66. DigisolHub UK
    Every business needs an online appearance nowadays. And in today’s world, where online shopping is increasing rapidly, e-commerce websites have become important for businesses. Building a website may sound easy, and you might make one for yourself, but it is hard for the website you make without any technical expertise for your business to be attractive enough for your business. ….read more

    ReplyDelete