If you haven't already heard, results from the phase I trial using human embryonic stem cells for patients with Stargardt's Disease and Macular Degeneration have been published in the Lancet, and the results are very promising!
Nine patients were treated from each disease which involved surgical implantation of the stem cells into the retina of one affected eye. The main aim of phase I trials is to test the safety of the intervention, so whether there were an adverse events or complications from having the stem cells implanted, and in this case whether the stem cells 'stuck' to the eye. The investigators also looked at whether there was any improvement in vision.
Excitingly, the results were very promising - there was no major adverse events (although some patients with Stargardt's developed cataracts but this was treated surgically and didn't affect vision after treatment), no rejection of the implanted cells, no abnormal tumour growth and it looked as though the cells remained functioning at follow-up (which was up to two years after initial implantation). To top it off, there was also objectively reported improvement in vision in the treated eye!
To put it in perspective, this is still early days and we won't be running out to get stem cells injected tomorrow. Although it is definitely looking like a very possible treatment in the future and in our lifetime! The next step is to proceed to a phase II trial which will include a larger number of patients and find the best dose (number of cells to be injected) to gain the best results. Further evidence of the effectiveness will be developed to show how much vision can be restored, if it is permanent, whether the implantation needs to be done in the early stages of the disease and many other questions.
This is extremely exciting and shows how amazing modern medical science can be. It can give us all a little more hope that potentially in the future we may be able to see better, and if not us, the generations to come who will unluckily have to experience the hurdles we have faced.
For more information here are the links to the results and news reports:
Wall Street Journal
The Lancet
Good news indeed, but unfortunately we are pretty far from a real cure .
ReplyDeleteStay strong .
DeleteAm jeremiah, I am testifying about a great hebal man that cured my wife of KIDNEY FAILURE AND hepatitis B and liver cirhosis. his name is Dr oniha. My wife was diagnose of hepatities two years ago, i almost spent all i had then, until i saw dr oniha recommendation online, and i call him, then he told me how to get the herb. You can call him on +2347089275769 or email him at dronihaspell@yahoo.com
I think this is very informative article which you have posted!! Most of the people are not aware about the eye disease as me. Through your post we will not be aware only but also be able to care for our best eyes.
ReplyDeleteThanks for being interested in our experiences :)
DeleteThat is so exciting that the stem cell research for your disease has improved so much! I cannot imagine what it would be like to have any kind of rare retinal disease, so congratulations for being such a warrior. We want to keep hearing updates about how all of the trials are going. Hopefully you can be a pioneer in this field.
ReplyDeletehttp://www.griffey2020.com
Thank you for taking an interest! I hope I can be too :)
Deletehello , my name is Florence . I have officially been diagnosed with Satgardts I am 12 and live in Italy , This is my blog
ReplyDeletehttp://florencewaddington.blogspot.it/
I am hopefully going to be on a clinical trial to here in Rome .
Thanks Florence and I hope you are doing ok with SD! I will put a link to your blog on mine. Keep me posted on how you're going :)
Deleteafter i read this, I think i really need an eye checkup
ReplyDeletehaha the bionic eye is a crazy piece of technology! There is one in development here in Australia that I've had my 'eye' on!
ReplyDeletepurtier placenta review :- Reverse the ageing process, combat age-related disorders and help treatment of various diseases by renewing the body cells with Stem Cell therapy..
ReplyDeleteExcellent post with Good information.
ReplyDeleteStem Cell Hospital.
Yeah dear, you are right dear, there are many eye disorders which are bizarre also and I think heterochromia disorder is also one of them. One of my friends is also affected with this problem.
ReplyDeletethose who keep have gained a pseudo enjoy this shortage from the upward pressure on wages given by the law of provide and demand still because the ample opportunities for them to require on second and third jobs, for more information click here physician palm beach gardens.
ReplyDeleteHey thanks for sharing such a nice post with us. Really love your post and keep looking for the new post. If you're india based eye surgeon then you can add your clinic into our website and get the more leads from all around the patients. Just visit here: Eye Surgeon in Ludhiana
ReplyDeleteYou completed a few fine points there. I did a search on the subject and found nearly all persons will go along with with your blog. Swiss Medica Review
ReplyDeleteYour blog provided us with valuable information to work with. Each & every tips of your post are awesome. Thanks a lot for sharing. Keep blogging.. swiss medica reviews and stem cells treatment reviews
ReplyDelete
ReplyDeleteBut Dr. Itua, Traditional Herbal Practitioner in Africa, Have cured for HIV which is extracted from some rare herbals. It is highly potential to cure AIDS 100% without any residue. Dr Itua herbal medicine has already passed various blogs on how he use his powerful herbals to heal all kind of diseases such as. Herpes, HIV,,Cushing’s disease,Heart failure,Multiple Sclerosis,Hypertension,Colo_Rectal Cancer, Diabetes, Hepatitis,Hpv,Weak ErectionLyme Disease,Blood Cancer,Alzheimer’s disease,Bechet’s disease,Crohn’s disease,Parkinson's disease,Schizophrenia,Lung Cancer,Breast Cancer,Colo-Rectal Cancer,Blood Cancer,Prostate Cancer,siva.Fatal Familial Insomnia Factor V Leiden Mutation ,Epilepsy Dupuytren's disease,Desmoplastic small-round-cell tumor Diabetes ,Coeliac disease,Creutzfeldt–Jakob disease,Cerebral Amyloid Angiopathy, Ataxia,Arthritis,Amyotrophic Lateral Scoliosis,Fibromyalgia,Fluoroquinolone Toxicity,Brain Cancer,Breast Cancer,Lung Cancer,Kidney Cancer,Syndrome Fibrodysplasia Ossificans ProgresSclerosis,Seizures,Alzheimer's disease,Adrenocortical carcinoma.Asthma,Allergic diseases.Hiv_ Aids,Herpe ,Copd,Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,
Dementia.,Wart Remover,Cold Sore, Epilepsy, also his herbal boost immune system as well. I'm telling this because he uses his herbal medicine to cure me from hepatitis B and HIV, which i have being living for 9 months now with no side effect. The Herbal Medicine is just as good when drinking it although i have to use rest room after drinking it which I do not really care about because i just want to get the virus out of my body, I will recommend Dr Itua to anyone sick out here to contact Dr Itua with this following information.
Email...drituaherbalcenter@gmail.com / info@drituaherbalcenter.com
Whatsapp Or Call...+2348149277967.
He might be late to respond because he always busy with patent, but he will surely get back to you with positive response.
Very inspirational to hear about someone pursuing their dream and becoming successful instead of following the traditional path.
ReplyDeletestem cell treatment for knees